Engineering replacement tissue to reverse damage to the central nervous system

BE Therapeutics is an early-stage biotech startup, developing technology to engineer functional brain and spinal cord tissue. Our mission is to engineer your very own replacement tissue to reverse age-related and other forms of damage to ensure indefinite function.

Stroke, trauma, neurodegeneration, and aging all cause permanent damage to the CNS.

No treatments enable afflicted individuals to regain lost functions.

BE Therapeutics aims to change this.

SUPPORTERS

TECHNOLOGY

Rather than try and re-invent the wheel, the technology at BE Therapeutics is guided by how our human brains first developed during the embryonic stage. Namely, BE Therapeutics is engineering a precursor tissue that mimics normal embryonic brain tissue, with the proper cell types, signaling cues, and structure, which allow this tissue to mature normally after transplantation, integrate with the host, and encode useful information for the patient.

BE Therapeutics' tissue and methodologies will be used in pre-clinical and clinical applications. The initial focus is on replacing damaged neocortical tissue, followed by other parts of the CNS.

Multi-cell type structured brain tissue

MEET THE TEAM

  • FOUNDER & former CSO Aug.2023-Jul2024

    From as far back as he can remember, he has been fascinated by what we, as living creatures, are made of. When he learned early on that a single cell forms the whole human body following an innate genetic program, he became driven by how this process might be used to improve our biological fates and defeat aging.

    This interest led him to do a Ph.D. in Genetics at the University of California, San Francisco, where with Dr. Gail Martin he studied the regulation of embryonic stem cell differentiation. Jean then moved to Stanford University for postdoctoral studies with Dr. Susan McConnell, where he focused on neural stem cells and how they generate the neocortex, the part of our brains that we use for our highest cognitive functions.

    Before founding BE, Jean became a Professor in Neuroscience and Genetics at the Albert Einstein College of Medicine, where his lab focused on cell and tissue-based approaches to reverse brain aging.

  • LEAD SCIENTIST

    Alex's first exposure to brain repair research occurred during her undergraduate internship in a mild traumatic brain injury lab led by Dr. Radouil Tzekov at the Roskamp Institute in Sarasota, Florida, while she was pursuing her undergraduate studies at New College of Florida. Shortly after obtaining her BA in Neurobiology under the mentorship of Dr. Alfred Beulig, she worked as a research technician in two immunology-based labs led by Dr. Edward Fisher and Dr. Joel Ernst at NYU Langone in NYC.

    After acquiring valuable cellular and molecular technical skills, Alex entered the PhD program at Albert Einstein College of Medicine in Bronx, NY, where she rekindled her true passion for Neuroscience. Joining Dr. Jean Hebert’s lab, she developed an in vivo platform to validate stem cell-derived grafts for cortical repair. Currently, Alex is the Lead Scientist at BE, applying her specialized expertise in stem cells and in vivo research to advance BE’s mission.

  • SENIOR TISSUE ENGINEER

    Wyndham began his scientific career studying Physics at the College of William & Mary in Williamsburg, VA; it was during this time that he had his first experience conducting research in biology and biophysics. Following his interest in applying techniques from the physical sciences to the biological world, Wyndham then completed his PhD in Biomedical Engineering at the University of Miami under Dr. Noel Ziebarth, where he was awarded the Graduate School Dean’s Fellowship.

    After graduation, Wyndham furthered his training in stem cell biology and regenerative medicine as a Postdoctoral Fellow at the National Institutes of Health under Dr. Tiansen Li, where he learned to utilize functional biomaterials to direct the growth and behavior of human stem cell derived retinal organoids.

    Wyndham now serves as the Senior Tissue Engineer at BE Therapeutics where he is developing novel biomaterial constructs for the creation of new functional brain tissue to be engrafted into damaged areas of the human brain.

  • SCIENTIST I

    Anna’s passion for neuroscience stems from her intrigue of how the biological building blocks in the brain give rise to complex thoughts and behaviors. To pursue this, she first received her BS in Neuroscience at New York University. During her undergraduate years, she conducted molecular neuroscience and behavioral research at New York University, the City University of New York, the University of Wisconsin, and Vanderbilt University. Her research was funded by fellowships from the National Science Foundation and the National Institutes of Health. Anna then received her PhD in Neuroscience from Johns Hopkins University.

    During her doctoral work with Dr. Jeremiah Cohen, she used an interdisciplinary approach to combine electrophysiology, molecular biology, and behavior to further investigate the link between the brain and behavior. At BE Therapeutics, Anna is a Scientist with a focus on in vivo, behavioral, and electrophysiology research.

  • SCIENTIST I

    Monika was fascinated with regenerative medicine since she was an undergraduate student of Biotechnology in Szczecin, Poland. Her fascination with soft tissue engineering led her into multiple internships, including Wageningen University in the Netherlands, Polish Academy of Sciences, and Warsaw University of Technology. Monika focused on mastering biological approaches combined with biomaterials and precise deposition by 3D bioprinting. Monika’s PhD work at the Pennsylvania State University under professorship of Dr. Jeffrey Catchmark, was focused on innovative biomaterials and bioprinted functional pancreas-on-a-chip device.

    After graduation Monika joined Biomics lab at CEA in Grenoble, France for a PostDoctoral project under mentorship of Prof. Xavier Gidrol, where she focused on PDAC initiation in a diabetic microenvironment. Following her interest in soft tissue engineering, Monika joined 3DBio Therapeutics company, where she was developing and translating innovative biological products and technologies from R&D to the clinic.

    At BE Therapeutics, Monika is a Scientist with a focus on biomaterials development and vascularization in vivo for the neocortex repair.

Let’s work together